5 Celebrities Who’ve Gone on GLP-1

Celebrity conversations about GLP-1 medications have moved from rumor to confirmed, on-the-record disclosures. That visibility has made many people more curious about what these drugs are, why they are prescribed, and what they can and cannot do. 

Brands and platforms across the wellness and health space are often mentioned in broader discussions about weight management trends, whether it’s Replenza helping GLP-1 users get the nutrition they need or specific GLP-1 drugs like Ozempic making headlines. 

Although the specifics are important, when it comes to celebrity experience, the most useful place to start is to focus on what has been publicly stated and separate media narratives from medical reality.

What Are GLP-1 Medications?

GLP-1 receptor agonists are prescription medications originally developed for conditions such as type 2 diabetes, and some GLP-1 medications are also approved for chronic weight management in certain patients. The public conversation often centers on weight loss, but it’s worth remembering that these are medical treatments that require clinical oversight.

These drugs generally work by influencing appetite regulation and metabolic processes. They may reduce hunger and help people feel full sooner. Even with that general mechanism, dosing, side effects, and outcomes depend on factors such as the specific medication used, health history, and how treatment is supervised. That is one reason why celebrity anecdotes can be interesting but should not be treated as universal templates.

Why Is Celebrity Awareness Important?

When a well-known figure talks about a GLP-1, the topic tends to spread quickly because celebrity news travels fast and gets repeated across outlets and social media. This can create two common problems. 

First, it can make a complex medical category feel like a simple lifestyle choice. Second, it can make it seem like results are immediate or uniform, even though real-world outcomes vary widely from person to person.

There is also a difference between confirmed disclosures and speculation. Many names get attached to these medications without evidence. The most accurate way to talk about celebrities who’ve gone on GLP-1 is to stick to cases where individuals have directly said they used one of these medications or where a reputable outlet has documented their statements.

Below, discover a few celebrities who have been open about their GLP-1 use in the public eye.

1. Oprah Winfrey

Oprah Winfrey has discussed GLP-1 use publicly in the context of long-term weight management and the stigma that often surrounds medical support. Her comments have been widely covered because they framed GLP-1 medications as part of an ongoing health plan rather than a short-term, cosmetic fix. Coverage has also highlighted how she connected her decision to broader conversations about biology, shame, and public scrutiny.

2. Amy Schumer

Amy Schumer has been unusually direct about both the upside and downside of GLP-1-related experiences. She has described losing weight on Ozempic but also dealing with severe side effects that made her stop taking it. Later, she shared that she was having a positive experience on Mounjaro, describing it as great for her.

These two disclosures are often referenced together because they show a more complete picture than the typical headline. The story was not framed as a single miracle outcome. Instead, it acknowledged that a medication that works well for one person can be difficult for another, and that switching or stopping a medication can be necessary for practical reasons.

3. Whoopi Goldberg

Whoopi Goldberg has also spoken publicly about using a GLP-1-related medication. Her disclosure has been frequently cited because it was presented as a personal health decision rather than a red-carpet trend. Coverage emphasized that she connected the medication to a specific moment in her health journey and discussed it in a straightforward way.

4. Sharon Osbourne

Sharon Osbourne has openly discussed using Ozempic and its downsides. She said publicly she was injecting Ozempic and described losing “too much” weight, along with challenges related to regaining weight afterward.

This is a reminder that celebrity disclosures do not always celebrate the experience. Some accounts highlight discomfort, unintended results, or the emotional and physical adjustment that can follow rapid change. It’s an important reminder of why it’s so important to still prioritize your nutrition while on GLP-1.

5. Chelsea Handler

Chelsea Handler has publicly discussed Ozempic, highlighting how casually these medications are discussed in certain circles. Handler said she didn’t know she was on Ozempic and described her doctor offering it as something that could help her lose a small amount of weight. 

Her disclosure often lands differently than others’ because it is less about a long-term treatment plan and more about access, messaging, and the broader culture around weight-loss solutions.

When Visibility Drives Better Information

Celebrity disclosures have helped normalize conversations about medical support for weight management, but they also increase the need for careful interpretation. The most responsible way to engage with these stories is to treat them as personal accounts, not universal guidance, and to rely on qualified medical professionals for individualized decisions. As more public figures speak openly, the conversation can become more realistic, especially when it includes context on side effects, long-term maintenance, and the limits of any medication.